P-Rex1 is a novel substrate of the E3 ubiquitin ligase Malin associated with Lafora disease
Laforin and Malin are two proteins that are encoded by the genes EPM2A and EPM2B, respectively.Laforin is a glucan phosphatase and Malin is an E3-ubiquitin ligase, and these two proteins function as a complex.Mutations occurring at the level of one of the two genes lead to the accumulation of an aberrant form of glycogen meant to cluster in polyglu